Reply: heterogeneous population

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Reply to Azuaje: Predicting effective combined therapies for heterogeneous tumors.

We thank Francisco J. Azuaje (1) for his comments regarding our article (2). His letter offers an opportunity for further discussion on the clinical relevance of heterogeneity drawn from our study using a computational optimization approach based on random sampling of RNAi-based perturbations. Our objective was to learn how to improve the design of drug combinations for diverse tumor subpopulat...

Heterogeneous landscapes promote population stability.

Habitat heterogeneity is often suggested as being important for the stability of populations, and promoted as a means to aid the conservation of species, but the evidence for such an assumption is poor. Here we show that heterogeneous landscapes that contain a variety of suitable habitat types are associated with more stable population dynamics for 35 British butterfly species from 166 sites. I...

The Authors’ Reply